ABSTRACT
Effects of a combination of medoxy-progesterone acetate (MPA) and dihydrotestosterone (DHT) at a dose of 10 mg + 2 mg/kg, injected, in weekly to rats of proven fertility were investigated with respect to their fertility, sperm and organ functions. This hormonal regimen had no effect in body and organ weights except in the testis. A depletion in sperm reserves in testis and epididymis was noted in addition to a loss of their motility in the later. Alterations in cauda epididymal sperm viability and morphology and reduced levels of superoxide dismutase indicated changes in their plasma membrane permeability. Sperm acrosomal enzymes such as acrosin and hyaluronidase were also affected leading to a loss of their function. Consequently the fertility potential of these rats also impaired after 60 days of hormonal regimen. Testicular biochemical machinery revealed its altered metabolism and regressed spermatogenic activity accounting for its loss of weight. Similarly epididymal physiology also exhibited changes leading to impaired sperm maturation. However, toxicity studies showed no significant variations in liver and blood biochemical profiles indicating non-toxic nature of this combination. All these effects seemed to be transient and reversible upon withdrawal of treatment for 60 and 90 days gradually. Thus, this combination with aromatizable androgen is useful for induction of functional sterility.
Subject(s)
Animals , Contraceptive Agents, Male/pharmacology , Dihydrotestosterone/administration & dosage , Fertility/drug effects , Male , Medroxyprogesterone Acetate/administration & dosage , RatsSubject(s)
Diagnosis, Differential , Electrocardiography , Heart Block/congenital , Humans , Male , Middle AgedABSTRACT
An unusual case of right atrial myxoma who had a ten year symptom free interval, following the initial manifestation is presented.
Subject(s)
Adult , Echocardiography , Heart Atria/pathology , Heart Neoplasms/diagnosis , Humans , Male , Myxoma/diagnosisABSTRACT
Real time colour blow mapping with doppler derived velocity profile of carotid vertebral arterial system in 26 normal controls, using Hewlett Packard Model HP 77020 equipment are presented. The normal peak velocities varied from 0.39 to 1.47 m/sec. The colour blow mapping of carotid-vertebral system, the first over to be published in India, to the best of our knowledge, enabled us to obtain more accurate carotid-vertebral arterial flows. Colour imaging makes it easy to differentiate normal from abnormal. We believe that colour blow mapping with Doppler studies will become the most important screening test for the evaluation of the extracranial carotid-vertebral system.